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  • Scope of the Suzuki-Miyaura cross-coupling reactions of potassium heteroaryltrifluoroborates.

Scope of the Suzuki-Miyaura cross-coupling reactions of potassium heteroaryltrifluoroborates.

The Journal of organic chemistry (2008-12-25)
Gary A Molander, Belgin Canturk, Lauren E Kennedy
ABSTRACT

A wide variety of bench-stable potassium heteroaryltrifluoroborates were prepared, and general reaction conditions were developed for their cross-coupling to aryl and heteroaryl halides. The cross-coupled products were obtained in good to excellent yields. This method represents an efficient and facile installation of heterocyclic building blocks onto preexisting organic substructures.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Potassium 2-methoxypyrimidin-5-yl-5-trifluoroborate, 90%
Sigma-Aldrich
Tetrafluoroboric acid, 49.5-50.5%
Sigma-Aldrich
Potassium 2-bromo-4-(trifluoromethyl)pyridine-3-trifluoroborate
Sigma-Aldrich
Tetrafluoroboric acid solution, 48 wt. % in H2O