- Construction of (Dihydro)naphtho[1,8- bc]pyrans via Rh(III)-Catalyzed Twofold C-H Activation of Benzoylacetonitriles.
Construction of (Dihydro)naphtho[1,8- bc]pyrans via Rh(III)-Catalyzed Twofold C-H Activation of Benzoylacetonitriles.
Organic letters (2018-04-03)
Panjie Hu, Ying Zhang, Youwei Xu, Shuang Yang, Bingxian Liu, Xingwei Li
PMID29607647
ABSTRACT
Rh(III)-catalyzed cascade C-H activation of benzoylacetonitriles and annulation with sulfoxonium ylides was realized, leading to selective synthesis of naphthols, 2,3-dihydronaphtho[1,8- bc]pyrans, and naphtho[1,8- bc]pyrans. This step-economic reaction proceeded efficiently under mild and redox-neutral conditions via multiple C-H activations.
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