MAK073
Sarcosine Assay Kit
sufficient for 100 colorimetric or fluorometric tests
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.84
Pricing and availability is not currently available.
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usage
sufficient for 100 colorimetric or fluorometric tests
detection method
colorimetric
fluorometric
relevant disease(s)
neurological disorders
storage temp.
−20°C
General description
Sarcosine, also known as N-methylglycine, is an amino acid that participates in one-carbon metabolism, serving as a one-carbon donor in mitochondrial reactions. Elevated levels of sarcosine may indicate deficiencies in Vitamin B12 and/or folate. Sarcosine is also an intermediate in glycine and choline metabolism. In the brain, sarcosine acts as an inhibitor of the type I glycine transporter, resulting in increased glycine levels and NMDA receptor activation suggesting it may be a therapeutic agent for the treatment of some mental illnesses such as schizophrenia, depression, or obsessive compulsive disorder.
Suitability
This kit is suitable for sarcosine detection in cell and tissue culture supernatants, plasma, serum, and other biological samples. Urine samples are not suitable for use with this assay because of sample interferences.
Principle
In this assay, sarcosine concentration is determined by a coupled enzyme reaction, which results in a colorimetric (570 nm)/fluorometric (λex = 535/λem = 587 nm) product, proportional to the sarcosine present.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1
Storage Class Code
10 - Combustible liquids
Flash Point(F)
188.6 °F - closed cup
Flash Point(C)
87 °C - closed cup
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