TXNRD1
thioredoxin reductase 1
Synonyms:
GRIM-12, TR, TR1, TRXR1, TXNR
Species:
Human TXNRD1 (7296), Mouse Txnrd1 (50493), Rat Txnrd1 (58819), Horse TXNRD1 (100067923), domestic cat TXNRD1 (101085222), domestic guinea pig Txnrd1 (100718723), Domestic Rabbit TXNRD1 (100356179), naked mole-rat Txnrd1 (101700382), dog TXNRD1 (474536), sheep TXNRD1 (101112970) ...More
UniProtKB ID:
Gene ID:
- Human(7296) Summary: This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(50493) thioredoxin reductase 1
- Rat(58819) thioredoxin reductase 1
- Horse(100067923) thioredoxin reductase 1
- domestic cat(101085222) thioredoxin reductase 1
- domestic guinea pig(100718723) thioredoxin reductase 1
- Domestic Rabbit(100356179) thioredoxin reductase 1
- naked mole-rat(101700382) thioredoxin reductase 1
- dog(474536) thioredoxin reductase 1
- sheep(101112970) thioredoxin reductase 1
- cow(282388) thioredoxin reductase 1
- chicken(418082) thioredoxin reductase 1
- Zebrafish(352924) thioredoxin reductase 1
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Activity Assay
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TXNRD1 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-TXNRD1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Proteins
Product Number
Description
Species
Thioredoxin Reductase from rat liver, buffered aqueous glycerol solution, ≥100 units/mg protein (Bradford),
Species
rat