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Merck

TPSAB1

tryptase alpha/beta 1

Synonyms:
TPS1, TPS2, TPSB1
Species:
Human TPSAB1 (7177), Mouse Tpsab1 (100503895), Rat Tpsab1 (54271)
UniProtKB ID:
Q15661, D2E6R9, D2E6S1, P15157, Q15663, Q6B052, Q9H2Y4, Q9H2Y5
Gene ID:
  • Human(7177) Summary: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
  • Mouse(100503895) tryptase alpha/beta 1
  • Rat(54271) tryptase alpha/beta 1

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Antibodies

Product Number
Description
Species Reactivity
Application
444905
Anti-Mast Cell Tryptase Mouse mAb (AA1), liquid, clone AA1, Calbiochem®,
Species Reactivity
canine, feline, human, monkey
Application
WH0007177M1
Monoclonal Anti-TPSAB1 antibody produced in mouse, clone 2A10-B5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
SAB4301600
Anti-TPSB2, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry

Proteins

Product Number
Description
Species
T7063
Tryptase from human lung, buffered aqueous solution, ≥5 units/mg protein,
Species
human