SMAD7
SMAD family member 7
Synonyms:
CRCS3, MADH7, MADH8
Species:
Human SMAD7 (4092), Mouse Smad7 (17131), Rat Smad7 (81516), dog SMAD7 (490570), domestic cat SMAD7 (101088277), Zebrafish smad7 (326282), chicken SMAD7 (429683), domestic guinea pig Smad7 (100717293), naked mole-rat Smad7 (101718588), sheep SMAD7 (443160) ...More
UniProtKB ID:
Gene ID:
- Human(4092) Summary: The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
- Mouse(17131) SMAD family member 7
- Rat(81516) SMAD family member 7
- dog(490570) SMAD family member 7
- domestic cat(101088277) SMAD family member 7
- Zebrafish(326282) MAD, mothers against decapentaplegic homolog 7 (Drosophila)
- chicken(429683) SMAD family member 7
- domestic guinea pig(100717293) SMAD family member 7
- naked mole-rat(101718588) SMAD family member 7
- sheep(443160) SMAD family member 7
- Horse(100033853) SMAD family member 7
- cow(535916) SMAD family member 7
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-SMAD7 antibody produced in mouse, clone 4E1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-SMAD7 (N-terminal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody, suitable for western blot: 2 μg/mL,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Monoclonal Anti-SMAD7 antibody produced in mouse, clone 3G8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-SMAD7 antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
Species Reactivity
bovine, human, monkey, mouse, rat
Application
immunofluorescence
western blot
western blot