SARS2
seryl-tRNA synthetase 2, mitochondrial
Synonyms:
SARS, SARSM, SERS, SYS, SerRS, SerRSmt, mtSerRS
Species:
Human SARS2 (54938), Mouse Sars2 (71984), Rat Sars2 (292759), domestic cat SARS2 (101093227), Zebrafish sars2 (394154), chicken SARS2 (100858214), naked mole-rat Sars2 (101718394), domestic guinea pig Sars2 (100730340), sheep SARS2 (101113878), dog SARS2 (484518)
UniProtKB ID:
Gene ID:
- Human(54938) Summary: This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
- Mouse(71984) seryl-aminoacyl-tRNA synthetase 2
- Rat(292759) seryl-tRNA synthetase 2, mitochondrial
- domestic cat(101093227) seryl-tRNA synthetase 2, mitochondrial
- Zebrafish(394154) seryl-tRNA synthetase 2, mitochondrial
- chicken(100858214) seryl-tRNA synthetase 2, mitochondrial
- naked mole-rat(101718394) seryl-tRNA synthetase 2, mitochondrial
- domestic guinea pig(100730340) seryl-tRNA synthetase 2, mitochondrial
- sheep(101113878) seryl-tRNA synthetase 2, mitochondrial
- dog(484518) seryl-tRNA synthetase 2, mitochondrial
- cow(282060) seryl-tRNA synthetase 2, mitochondrial
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