PSMC4
proteasome (prosome, macropain) 26S subunit, ATPase, 4
Synonyms:
MIP224, RPT3, S6, TBP-7, TBP7
Species:
Human PSMC4 (5704), Mouse Psmc4 (23996), Rat Psmc4 (117262), Zebrafish psmc4 (326884), domestic guinea pig Psmc4 (100727625), naked mole-rat Psmc4 (101717896), sheep PSMC4 (101117608), Domestic Rabbit PSMC4 (100341658), cow PSMC4 (510029), Horse PSMC4 (100064604) ...More
UniProtKB ID:
Gene ID:
- Human(5704) Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
- Mouse(23996) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- Rat(117262) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- Zebrafish(326884) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- domestic guinea pig(100727625) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- naked mole-rat(101717896) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- sheep(101117608) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- Domestic Rabbit(100341658) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- cow(510029) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- Horse(100064604) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- domestic cat(101090224) proteasome (prosome, macropain) 26S subunit, ATPase, 4
- dog(476459) proteasome (prosome, macropain) 26S subunit, ATPase, 4
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