PMEL
premelanosome protein
Synonyms:
D12S53E, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV, gp100
Species:
Human PMEL (6490), Mouse Pmel (20431), Rat Pmel (362818), chicken PMEL (396007), domestic guinea pig Pmel (100714975), naked mole-rat Pmel (101724736), cow PMEL (281487), sheep PMEL (101112637), Domestic Rabbit PMEL (100347477), dog PMEL (481102)
UniProtKB ID:
Gene ID:
- Human(6490) Summary: This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
- Mouse(20431) premelanosome protein
- Rat(362818) premelanosome protein
- chicken(396007) premelanosome protein
- domestic guinea pig(100714975) premelanosome protein
- naked mole-rat(101724736) premelanosome protein
- cow(281487) premelanosome protein
- sheep(101112637) premelanosome protein
- Domestic Rabbit(100347477) premelanosome protein
- dog(481102) premelanosome protein
- domestic cat(101092774) premelanosome protein
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