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Merck

PDK1

pyruvate dehydrogenase kinase, isozyme 1

Synonyms:
Species:
Human PDK1 (5163), Mouse Pdk1 (228026), Rat Pdk1 (116551), fruit fly Pdk1 (38017), Zebrafish pdk1 (555840), Thale Cress PDK1 (830330), Horse PDK1 (100064091), domestic guinea pig Pdk1 (100715937), naked mole-rat Pdk1 (101705587), sheep PDK1 (101113205) ...More
UniProtKB ID:
Q15118, B2R6T1, D3DPD8
Gene ID:
  • Human(5163) Summary: Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]
  • Mouse(228026) pyruvate dehydrogenase kinase, isoenzyme 1
  • Rat(116551) pyruvate dehydrogenase kinase, isozyme 1
  • fruit fly(38017) Phosphoinositide-dependent kinase 1
  • Zebrafish(555840) pyruvate dehydrogenase kinase, isozyme 1
  • Thale Cress(830330) 3'-phosphoinositide-dependent protein kinase 1
  • Horse(100064091) pyruvate dehydrogenase kinase, isozyme 1
  • domestic guinea pig(100715937) pyruvate dehydrogenase kinase, isozyme 1
  • naked mole-rat(101705587) pyruvate dehydrogenase kinase, isozyme 1
  • sheep(101113205) pyruvate dehydrogenase kinase, isozyme 1
  • Domestic Rabbit(100351323) pyruvate dehydrogenase kinase, isozyme 1
  • cow(528655) pyruvate dehydrogenase kinase, isozyme 1
  • domestic cat(101092705) pyruvate dehydrogenase kinase, isozyme 1
  • dog(476828) pyruvate dehydrogenase kinase, isozyme 1
  • chicken(425972) pyruvate dehydrogenase kinase, isozyme 1

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Small Molecule - Activator

Product Number
Description
Species
D54702
Dichloroacetic acid, ReagentPlus®, ≥99%,
Species
human, rat

Small Molecule - Inhibitor

Product Number
Description
Species
D54702
Dichloroacetic acid, ReagentPlus®, ≥99%,
Species
human, rat
347795
Sodium dichloroacetate, 98%,
Species
human

Proteins

Product Number
Description
Species
SRP5247
PDHK1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human