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Merck

PCDHGA5

protocadherin gamma subfamily A, 5

Synonyms:
CDH-GAMMA-A5, ME3, PCDH-GAMMA-A5
Species:
Human PCDHGA5 (56110), Mouse Pcdhga5 (93713), Rat Pcdhga5 (291637), cow PCDHGA5 (539653), naked mole-rat Pcdhga5 (101699484), dog PCDHGA5 (487181), Horse PCDHGA5 (100061508), sheep PCDHGA5 (101105244), Domestic Rabbit PCDHGA5 (100353908), domestic cat PCDHGA5 (101098190)
UniProtKB ID:
Q9Y5G8, Q2M3F5, Q9Y5D2
Gene ID:
  • Human(56110) Summary: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
  • Mouse(93713) protocadherin gamma subfamily A, 5
  • Rat(291637) protocadherin gamma subfamily A, 5
  • cow(539653) protocadherin gamma subfamily A, 5
  • naked mole-rat(101699484) protocadherin gamma subfamily A, 5
  • dog(487181) protocadherin gamma subfamily A, 5
  • Horse(100061508) protocadherin gamma subfamily A, 5
  • sheep(101105244) protocadherin gamma subfamily A, 5
  • Domestic Rabbit(100353908) protocadherin gamma subfamily A, 5
  • domestic cat(101098190) protocadherin gamma subfamily A, 5

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