NDUFA5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
Synonyms:
B13, CI-13KD-B, CI-13kB, NUFM, UQOR13
Species:
Human NDUFA5 (4698), Mouse Ndufa5 (68202), Rat Ndufa5 (25488), naked mole-rat Ndufa5 (101701548), domestic guinea pig Ndufa5 (100723200), domestic cat NDUFA5 (101092508), cow NDUFA5 (327714), sheep NDUFA5 (101123463), Zebrafish ndufa5 (541328), chicken NDUFA5 (417753)
UniProtKB ID:
Gene ID:
- Human(4698) Summary: The human NDUFA5 gene codes for the B13 subunit of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. The high degree of conservation of NDUFA5 extending to plants and fungi indicates its functional significance in the enzyme complex. The protein localizes to the inner mitochondrial membrane as part of the 7 component-containing, water soluble 'iron-sulfur protein' (IP) fraction of complex I, although its specific role is unknown. It is assumed to undergo post-translational removal of the initiator methionine and N-acetylation of the next amino acid. The predicted secondary structure is primarily alpha helix, but the carboxy-terminal half of the protein has high potential to adopt a coiled-coil form. The amino-terminal part contains a putative beta sheet rich in hydrophobic amino acids that may serve as mitochondrial import signal. Related pseudogenes have also been identified on four other chromosomes. [provided by RefSeq, Jul 2008]
- Mouse(68202) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
- Rat(25488) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 5
- naked mole-rat(101701548) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa
- domestic guinea pig(100723200) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
- domestic cat(101092508) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa
- cow(327714) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa
- sheep(101123463) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa
- Zebrafish(541328) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
- chicken(417753) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa
- dog(475214) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa
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Small Molecule - Inhibitor
Product Number
Description
Species
Metformin hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human