KDELR2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
Synonyms:
ELP-1, ERD2.2
Species:
Human KDELR2 (11014), Mouse Kdelr2 (66913), Rat Kdelr2 (304290), sheep KDELR2 (101116624), domestic cat KDELR2 (101100774), dog KDELR2 (612839), cow KDELR2 (531676), Goat KDELR2 (100861344), chicken KDELR2 (771927), domestic guinea pig Kdelr2 (100727948)
UniProtKB ID:
Gene ID:
- Human(11014) Summary: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
- Mouse(66913) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
- Rat(304290) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
- sheep(101116624) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
- domestic cat(101100774) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
- dog(612839) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
- cow(531676) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
- Goat(100861344) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
- chicken(771927) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
- domestic guinea pig(100727948) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
- naked mole-rat(101701913) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-KDELR2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot