KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3
Synonyms:
GIRK1, KGA, KIR3.1
Species:
Human KCNJ3 (3760), Mouse Kcnj3 (16519), Rat Kcnj3 (50599), dog KCNJ3 (488355), chicken KCNJ3 (396369), sheep KCNJ3 (101115095), cow KCNJ3 (526088), domestic cat KCNJ3 (101088179), naked mole-rat Kcnj3 (101718832), domestic guinea pig Kcnj3 (100190980)
UniProtKB ID:
Gene ID:
- Human(3760) Summary: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012]
- Mouse(16519) potassium inwardly-rectifying channel, subfamily J, member 3
- Rat(50599) potassium inwardly-rectifying channel, subfamily J, member 3
- dog(488355) potassium inwardly-rectifying channel, subfamily J, member 3
- chicken(396369) potassium inwardly-rectifying channel, subfamily J, member 3
- sheep(101115095) potassium inwardly-rectifying channel, subfamily J, member 3
- cow(526088) potassium inwardly-rectifying channel, subfamily J, member 3
- domestic cat(101088179) potassium inwardly-rectifying channel, subfamily J, member 3
- naked mole-rat(101718832) potassium inwardly-rectifying channel, subfamily J, member 3
- domestic guinea pig(100190980) potassium inwardly-rectifying channel, subfamily J, member 3
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