HUS1
HUS1 checkpoint homolog (S. pombe)
Synonyms:
hHUS1
Species:
Human HUS1 (3364), Mouse Hus1 (15574), Rat Hus1 (498411), sheep HUS1 (101113059), dog HUS1 (606789), domestic cat HUS1 (101081456), Horse HUS1 (100066083), naked mole-rat Hus1 (101704977), domestic guinea pig Hus1 (100713541), chicken HUS1 (428471)
UniProtKB ID:
Gene ID:
- Human(3364) Summary: The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
- Mouse(15574) Hus1 homolog (S. pombe)
- Rat(498411) HUS1 checkpoint homolog (S. pombe)
- sheep(101113059) HUS1 checkpoint homolog (S. pombe)
- dog(606789) HUS1 checkpoint homolog (S. pombe)
- domestic cat(101081456) HUS1 checkpoint homolog (S. pombe)
- Horse(100066083) HUS1 checkpoint homolog (S. pombe)
- naked mole-rat(101704977) HUS1 checkpoint homolog (S. pombe)
- domestic guinea pig(100713541) HUS1 checkpoint homolog (S. pombe)
- chicken(428471) HUS1 checkpoint homolog (S. pombe)
- cow(514142) HUS1 checkpoint homolog (S. pombe)
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