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Merck

HTR2B

5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled

Synonyms:
5-HT(2B), 5-HT2B
Species:
UniProtKB ID:
Gene ID:
  • Human(3357) Summary: This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]
  • Mouse(15559) 5-hydroxytryptamine (serotonin) receptor 2B
  • Rat(29581) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • chicken(395581) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • Zebrafish(751784) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • dog(403881) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • cow(407135) 5-hydroxytryptamine (serotonin) receptor 2B
  • Horse(100057052) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • domestic cat(101095762) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • Domestic Rabbit(100343392) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • sheep(101106827) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • naked mole-rat(101699201) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • domestic guinea pig(100135546) 5-hydroxytryptamine (serotonin) receptor 2B

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Small Molecule - Agonist

Product Number
Description
Species
BW 723C86, ≥98% (HPLC),
Species
human
Methylergonovine maleate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Methylergometrine for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Methylergometrine maleate, European Pharmacopoeia (EP) Reference Standard,
Species
human
(R)(−)-DOI hydrochloride, ≥98% (HPLC), solid,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
DCEBIO, ≥98% (HPLC), solid,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
SB-215505, solid, >98% (HPLC),
Species
human
Methylergonovine maleate, United States Pharmacopeia (USP) Reference Standard,
Species
human
SB-206553 hydrochloride hydrate, ≥98% (HPLC), solid,
Species
human
Methylergometrine for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Methylergometrine maleate, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-5-HT-2B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-HTR2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-HTR2B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot
Anti-Serotonin 5-HT2B Receptor antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry

Small Molecule - Blocker

Product Number
Description
Species
Mianserin hydrochloride, ,
Species
human
6-Nitroquipazine maleate salt, solid,
Species
human
Trimipramine maleate salt, ≥98% (TLC), powder,
Species
human
Zimelidine dihydrochloride, solid,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Nortriptyline hydrochloride, ≥98% (HPLC), powder,
Species
human
Amoxapine, ,
Species
human
Minaprine dihydrochloride, analytical standard,
Species
human, rat
S-(+)-Fluoxetine hydrochloride, ≥98% (HPLC), solid,
Species
human
R-(−)-Fluoxetine hydrochloride, >98% (HPLC), solid,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
Minaprine dihydrochloride, analytical standard,
Species
human, rat
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
Species
human

Small Molecule - Metabolite

Product Number
Description
Species
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
Mifepristone, ≥98%,
Species
human, mouse, rat
Clozapine, ,
Species
human, rat

Small Molecule - Precursor

Product Number
Description
Species
5-Hydroxy-L-tryptophan, powder,
Species
human