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Merck

GRIN1

glutamate receptor, ionotropic, N-methyl D-aspartate 1

Synonyms:
GluN1, MRD8, NMDA1, NMDAR1, NR1
Species:
UniProtKB ID:
Gene ID:
  • Human(2902) Summary: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
  • Mouse(14810) glutamate receptor, ionotropic, NMDA1 (zeta 1)
  • Rat(24408) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • naked mole-rat(101720185) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • Horse(100059861) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • chicken(404296) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • sheep(443281) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • cow(100336579) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • domestic guinea pig(100301989) glutamate receptor, ionotropic, NMDA1 (zeta 1)
  • dog(494007) glutamate receptor, ionotropic, N-methyl D-aspartate 1

Custom & Knockdown Gene Products

Small Molecule - Agonist

Product Number
Description
Species
Spermine tetrahydrochloride, powder or crystals,
Species
human
D-Serine, ≥98% (TLC),
Species
human
Taurine, ≥99%,
Species
human, rat
D-Cycloserine, synthetic,
Species
human
N-Methyl-D-aspartic acid, ≥98% (TLC), solid,
Species
human, rat

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Acamprosate calcium, ≥98% (HPLC), powder,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
CP-101,606, ≥98% (HPLC),
Species
human
MDL 105,519, ≥98% (HPLC), solid,
Species
rat, human
L-701,324, ≥98% (HPLC), solid,
Species
rat, human
Arcaine sulfate salt, ,
Species
human
Dextrorphan tartrate, powder,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GRIN1 (Ab-897) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
Anti-phospho-GRIN1 (pSer896) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Glutamate Receptor NMDAR1 (NR1) (Splice Variant Insert N1) antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Species Reactivity
rat
Application
dot blot
immunohistochemistry

western blot
Anti-NMDA Receptor 1/GRIN1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
Anti-NMDAR1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot

Small Molecule - Blocker

Product Number
Description
Species
Philanthotoxin 433 tris(trifluoroacetate) salt, ≥98% (HPLC), powder,
Species
mouse, rat, human
N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid,
Species
human
Agmatine sulfate salt, ≥97%, powder,
Species
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Species
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Taurine, ≥99%,
Species
human, rat
Pentamidine isethionate salt, powder,
Species
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Species
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human

Proteins

Product Number
Description
Species
PrEST Antigen GRIN1, Prestige Antibodies® Powered by Atlas Antibodies, buffered aqueous solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GRIN1,
Species
human