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Merck

GRAP

GRB2-related adaptor protein

Synonyms:
Species:
Human GRAP (10750), Mouse Grap (71520), Rat Grap (363616), chicken GRAP (416523), domestic cat GRAP (101085758), dog GRAP (489534), fruit fly grap (45433), naked mole-rat Grap (101721246), cow GRAP (534491), domestic guinea pig Grap (100727005)
UniProtKB ID:
Q13588
Gene ID:
  • Human(10750) Summary: This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]
  • Mouse(71520) GRB2-related adaptor protein
  • Rat(363616) GRB2-related adaptor protein
  • chicken(416523) GRB2-related adaptor protein
  • domestic cat(101085758) GRB2-related adaptor protein
  • dog(489534) GRB2-related adaptor protein
  • fruit fly(45433) grape
  • naked mole-rat(101721246) GRB2-related adaptor protein
  • cow(534491) GRB2-related adaptor protein
  • domestic guinea pig(100727005) GRB2-related adaptor protein
  • sheep(101110605) GRB2-related adaptor protein

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