Skip to Content
Merck

GPBAR1

G protein-coupled bile acid receptor 1

Synonyms:
BG37, GPCR19, GPR131, M-BAR, TGR5
Species:
Human GPBAR1 (151306), Mouse Gpbar1 (227289), Rat Gpbar1 (338443), naked mole-rat Gpbar1 (101710900), domestic guinea pig Gpbar1 (100723590), sheep GPBAR1 (101109073), cow GPBAR1 (317756), domestic cat GPBAR1 (101089457), dog GPBAR1 (488521)
UniProtKB ID:
Q8TDU6, B3KV35
Gene ID:
  • Human(151306) Summary: This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
  • Mouse(227289) G protein-coupled bile acid receptor 1
  • Rat(338443) G protein-coupled bile acid receptor 1
  • naked mole-rat(101710900) G protein-coupled bile acid receptor 1
  • domestic guinea pig(100723590) G protein-coupled bile acid receptor 1
  • sheep(101109073) G protein-coupled bile acid receptor 1
  • cow(317756) G protein-coupled bile acid receptor 1
  • domestic cat(101089457) G protein-coupled bile acid receptor 1
  • dog(488521) G protein-coupled bile acid receptor 1

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.