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Merck

GLUD1

glutamate dehydrogenase 1

Synonyms:
GDH, GDH1, GLUD
Species:
UniProtKB ID:
Gene ID:
  • Human(2746) Summary: This gene encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.[provided by RefSeq, Sep 2009]
  • Mouse(14661) glutamate dehydrogenase 1
  • Rat(24399) glutamate dehydrogenase 1
  • naked mole-rat(101699446) glutamate dehydrogenase 1
  • domestic guinea pig(100722523) glutamate dehydrogenase 1
  • sheep(443239) glutamate dehydrogenase 1
  • cow(281785) glutamate dehydrogenase 1
  • dog(100684847) glutamate dehydrogenase 1
  • chicken(423612) glutamate dehydrogenase 1

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GLUD1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-GLUD1, affinity isolated antibody,
Species Reactivity
bovine, dog, horse, human, mouse, pig, rabbit, rat, sheep
Application
immunohistochemistry
western blot
Anti-GLUD1 / GLUD2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, canine, human, mouse, rat
Application
ELISA
immunohistochemistry

western blot

Kits

Product Number
Description
Species
Glutamate Dehydrogenase (GDH) Activity Assay Kit, sufficient for 100 colorimetric tests,
Species
mouse, rat, human

Proteins

Product Number
Description
Species
L-Glutamic Dehydrogenase from bovine liver, Type II, 50% glycerol solution, ≥35 units/mg protein,
Species
cow
L-Glutamic Dehydrogenase from bovine liver, Type III, lyophilized powder, ≥20 units/mg protein,
Species
cow
L-Glutamic Dehydrogenase from bovine liver, Type I, ammonium sulfate suspension, ≥40 units/mg protein,
Species
cow