GCK
glucokinase (hexokinase 4)
Synonyms:
FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
Species:
Human GCK (2645), Mouse Gck (103988), Rat Gck (24385), Zebrafish gck (751668), chicken GCK (430370), domestic cat GCK (100037406), dog GCK (606490), sheep GCK (101117412), cow GCK (616576), Horse GCK (100051836) ...More
UniProtKB ID:
Gene ID:
- Human(2645) Summary: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]
- Mouse(103988) glucokinase
- Rat(24385) glucokinase
- Zebrafish(751668) glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
- chicken(430370) glucokinase (hexokinase 4)
- domestic cat(100037406) glucokinase (hexokinase 4)
- dog(606490) glucokinase (hexokinase 4)
- sheep(101117412) glucokinase (hexokinase 4)
- cow(616576) glucokinase (hexokinase 4)
- Horse(100051836) glucokinase (hexokinase 4)
- naked mole-rat(101721664) glucokinase (hexokinase 4)
- domestic guinea pig(100717630) glucokinase (hexokinase 4)
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Custom Gene Products
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Kits
Product Number
Description
Species
Hexokinase Colorimetric Assay Kit, sufficient for 100 colorimetric tests,
Species
mouse, rat, human