F13B
coagulation factor XIII, B polypeptide
Synonyms:
FXIIIB
Species:
Human F13B (2165), Mouse F13b (14060), Rat F13b (289055), Zebrafish f13b (100329235), naked mole-rat F13b (101714935), chicken F13B (424355), dog F13B (490261), domestic cat F13B (101091588), Horse F13B (100060602), domestic guinea pig F13b (100733621) ...More
UniProtKB ID:
Gene ID:
- Human(2165) Summary: This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
- Mouse(14060) coagulation factor XIII, beta subunit
- Rat(289055) coagulation factor XIII, B polypeptide
- Zebrafish(100329235) coagulation factor XIII, B polypeptide
- naked mole-rat(101714935) coagulation factor XIII, B polypeptide
- chicken(424355) coagulation factor XIII, B polypeptide
- dog(490261) coagulation factor XIII, B polypeptide
- domestic cat(101091588) coagulation factor XIII, B polypeptide
- Horse(100060602) coagulation factor XIII, B polypeptide
- domestic guinea pig(100733621) coagulation factor XIII, B polypeptide
- sheep(101122712) coagulation factor XIII, B polypeptide
- cow(511483) coagulation factor XIII, B polypeptide
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-F13B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, guinea pig, human, mouse, rat
Application
western blot