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Merck

F12

coagulation factor XII (Hageman factor)

Synonyms:
HAE3, HAEX, HAF
Species:
Human F12 (2161), Mouse F12 (58992), Rat F12 (306761), naked mole-rat F12 (101720589), domestic guinea pig F12 (100728720), Domestic Rabbit F12 (100351481), sheep F12 (101106770), cow F12 (280789), Horse F12 (100068589), domestic cat F12 (100313488)
UniProtKB ID:
P00748, P78339
Gene ID:
  • Human(2161) Summary: This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]
  • Mouse(58992) coagulation factor XII (Hageman factor)
  • Rat(306761) coagulation factor XII (Hageman factor)
  • naked mole-rat(101720589) coagulation factor XII (Hageman factor)
  • domestic guinea pig(100728720) coagulation factor XII (Hageman factor)
  • Domestic Rabbit(100351481) coagulation factor XII (Hageman factor)
  • sheep(101106770) coagulation factor XII (Hageman factor)
  • cow(280789) coagulation factor XII (Hageman factor)
  • Horse(100068589) coagulation factor XII (Hageman factor)
  • domestic cat(100313488) coagulation factor XII (Hageman factor)
  • dog(489090) coagulation factor XII (Hageman factor)

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4500831
Anti-FA12 (heavy chain, Cleaved-Arg372) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot
SAB2104822
Anti-F12, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot