DUSP12
dual specificity phosphatase 12
Synonyms:
DUSP1, YVH1
Species:
Human DUSP12 (11266), Mouse Dusp12 (80915), Rat Dusp12 (64014), naked mole-rat Dusp12 (101705133), dog DUSP12 (478985), sheep DUSP12 (101107242), domestic guinea pig Dusp12 (100715676), Zebrafish dusp12 (573998), chicken DUSP12 (425349), cow DUSP12 (505302)
UniProtKB ID:
Gene ID:
- Human(11266) Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]
- Mouse(80915) dual specificity phosphatase 12
- Rat(64014) dual specificity phosphatase 12
- naked mole-rat(101705133) dual specificity phosphatase 12
- dog(478985) dual specificity phosphatase 12
- sheep(101107242) dual specificity phosphatase 12
- domestic guinea pig(100715676) dual specificity phosphatase 12
- Zebrafish(573998) dual specificity phosphatase 12
- chicken(425349) dual specificity phosphatase 12
- cow(505302) dual specificity phosphatase 12
- domestic cat(101087296) dual specificity phosphatase 12
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