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Merck

DIABLO

diablo, IAP-binding mitochondrial protein

Synonyms:
DFNA64, SMAC
Species:
Human DIABLO (56616), Mouse Diablo (66593), Rat Diablo (288753), chicken DIABLO (416860), cow DIABLO (493999), domestic guinea pig Diablo (100724526), naked mole-rat Diablo (101708166), sheep DIABLO (101121971), dog DIABLO (477463)
UniProtKB ID:
Q9NR28, B2RDQ0, Q6W3F3, Q96LV0, Q9BT11, Q9HAV6
Gene ID:
  • Human(56616) Summary: This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
  • Mouse(66593) diablo homolog (Drosophila)
  • Rat(288753) diablo, IAP-binding mitochondrial protein
  • chicken(416860) diablo, IAP-binding mitochondrial protein
  • cow(493999) diablo, IAP-binding mitochondrial protein
  • domestic guinea pig(100724526) diablo, IAP-binding mitochondrial protein
  • naked mole-rat(101708166) diablo, IAP-binding mitochondrial protein
  • sheep(101121971) diablo, IAP-binding mitochondrial protein
  • dog(477463) diablo, IAP-binding mitochondrial protein

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ELISA

Product Number
Description
Species
RAB0912
Rat DIABLO / Diablo Homolog (Drosophila) ELISA Kit, ,
Species
rat
RAB0841
Mouse Diablo / Diablo Homolog, Mitochondrial ELISA Kit, ,
Species
mouse

Antibodies

Product Number
Description
Species Reactivity
Application
PRS2411
Anti-SMAC antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
AB3609
Anti-Smac/Diablo Antibody, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
western blot