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Merck

DEFA6

defensin, alpha 6, Paneth cell-specific

Synonyms:
DEF6, HD-6
Species:
Human DEFA6 (1671), Mouse Defa6 (13240), Rat Defa6 (613223), Horse DEFA6 (100307029)
UniProtKB ID:
Q01524
Gene ID:
  • Human(1671) Summary: Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Jul 2008]
  • Mouse(13240) defensin, alpha, 6
  • Rat(613223) defensin alpha 6
  • Horse(100307029) defensin, alpha 6, Paneth cell-specific

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