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Merck

CYP24A1

cytochrome P450, family 24, subfamily A, polypeptide 1

Synonyms:
CP24, CYP24, HCAI, P450-CC24
Species:
Human CYP24A1 (1591), Mouse Cyp24a1 (13081), Rat Cyp24a1 (25279), chicken CYP24A1 (395827), dog CYP24A1 (485935), domestic cat CYP24A1 (101096141), cow CYP24A1 (540080), Zebrafish cyp24a1 (100004700)
UniProtKB ID:
Q07973, Q15807, Q32ML3
Gene ID:
  • Human(1591) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(13081) cytochrome P450, family 24, subfamily a, polypeptide 1
  • Rat(25279) cytochrome P450, family 24, subfamily a, polypeptide 1
  • chicken(395827) cytochrome P450, family 24, subfamily A, polypeptide 1
  • dog(485935) cytochrome P450, family 24, subfamily A, polypeptide 1
  • domestic cat(101096141) cytochrome P450, family 24, subfamily A, polypeptide 1
  • cow(540080) cytochrome P450, family 24, subfamily A, polypeptide 1
  • Zebrafish(100004700) cytochrome P450, family 24, subfamily A, polypeptide 1

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Antibodies

Product Number
Description
Species Reactivity
Application
WH0001591M7
Monoclonal Anti-CYP24A1 antibody produced in mouse, clone 1F8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
SAB4500611
Anti-Cytochrome P450 24A1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
UC280
Ketoconazole, ,
Species
mouse, human, rat
K1003
Ketoconazole, 99.0-101.0% (EP, titration), meets EP testing specifications,
Species
mouse, human, rat