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Merck

CLCF1

cardiotrophin-like cytokine factor 1

Synonyms:
BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6
Species:
Human CLCF1 (23529), Mouse Clcf1 (56708), Rat Clcf1 (365395), domestic guinea pig Clcf1 (100721145), naked mole-rat Clcf1 (101706033), dog CLCF1 (483697), cow CLCF1 (100336481), sheep CLCF1 (101108788), chicken CLCF1 (100858060), domestic cat CLCF1 (101101338)
UniProtKB ID:
Q9UBD9, B4DNT4, Q6NZA4
Gene ID:
  • Human(23529) Summary: This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
  • Mouse(56708) cardiotrophin-like cytokine factor 1
  • Rat(365395) cardiotrophin-like cytokine factor 1
  • domestic guinea pig(100721145) cardiotrophin-like cytokine factor 1
  • naked mole-rat(101706033) cardiotrophin-like cytokine factor 1
  • dog(483697) cardiotrophin-like cytokine factor 1
  • cow(100336481) cardiotrophin-like cytokine factor 1
  • sheep(101108788) cardiotrophin-like cytokine factor 1
  • chicken(100858060) cardiotrophin-like cytokine factor 1
  • domestic cat(101101338) cardiotrophin-like cytokine factor 1

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1407221
Anti-CLCF1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot