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Merck

CHUK

conserved helix-loop-helix ubiquitous kinase

Synonyms:
IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
Species:
Human CHUK (1147), Mouse Chuk (12675), Rat Chuk (309361), Zebrafish chuk (393287), naked mole-rat Chuk (101719306), domestic guinea pig Chuk (100726357), sheep CHUK (101111143), cow CHUK (281073), Horse CHUK (100070393), domestic cat CHUK (101095617) ...More
UniProtKB ID:
O15111, O14666, Q13132, Q5W0I4, Q92467
Gene ID:
  • Human(1147) Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]
  • Mouse(12675) conserved helix-loop-helix ubiquitous kinase
  • Rat(309361) conserved helix-loop-helix ubiquitous kinase
  • Zebrafish(393287) conserved helix-loop-helix ubiquitous kinase
  • naked mole-rat(101719306) conserved helix-loop-helix ubiquitous kinase
  • domestic guinea pig(100726357) conserved helix-loop-helix ubiquitous kinase
  • sheep(101111143) conserved helix-loop-helix ubiquitous kinase
  • cow(281073) conserved helix-loop-helix ubiquitous kinase
  • Horse(100070393) conserved helix-loop-helix ubiquitous kinase
  • domestic cat(101095617) conserved helix-loop-helix ubiquitous kinase
  • dog(477796) conserved helix-loop-helix ubiquitous kinase
  • chicken(423669) conserved helix-loop-helix ubiquitous kinase

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4301429
Anti-phospho-IKK-α/β (pSer180/181) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
SAB4300396
Anti-CHUK (Ab-23) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
ZRB1673
Anti-p-IKKα/β-Ser176/180 Antibody, clone 2G2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, canine, feline, human, monkey, mouse, porcine, rat
Application
affinity binding assay
immunohistochemistry
inhibition assay
western blot
SAB4300106
Anti-phospho-CHUK (pThr23) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
OP133
Anti-IKKα Mouse mAb (14A231), liquid, clone 14A231, Calbiochem®,
Species Reactivity
human, monkey, mouse
Application

Proteins

Product Number
Description
Species
SRP5040
IKK α , active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
14-461-M
IKKα Protein, active, 10 µg, Active, recombinant full-length human IKKα, containing an N-terminal GST-tag, for use in Kinase Assays.,
Species
human

Small Molecule - Substrate

Product Number
Description
Species
12-459
IKK Substrate Peptide, ,
Species
human