ATP2B3
ATPase, Ca++ transporting, plasma membrane 3
Synonyms:
PMCA3, PMCA3a, SCAX1
Species:
Human ATP2B3 (492), Mouse Atp2b3 (320707), Rat Atp2b3 (29599), domestic cat ATP2B3 (101101451), Domestic Rabbit ATP2B3 (100356760), cow ATP2B3 (504353), sheep ATP2B3 (101101873), domestic guinea pig Atp2b3 (100729216), dog ATP2B3 (492238), naked mole-rat Atp2b3 (101713508)
UniProtKB ID:
Gene ID:
- Human(492) Summary: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- Mouse(320707) ATPase, Ca++ transporting, plasma membrane 3
- Rat(29599) ATPase, Ca++ transporting, plasma membrane 3
- domestic cat(101101451) ATPase, Ca++ transporting, plasma membrane 3
- Domestic Rabbit(100356760) ATPase, Ca++ transporting, plasma membrane 3
- cow(504353) ATPase, Ca++ transporting, plasma membrane 3
- sheep(101101873) ATPase, Ca++ transporting, plasma membrane 3
- domestic guinea pig(100729216) ATPase, Ca++ transporting, plasma membrane 3
- dog(492238) ATPase, Ca++ transporting, plasma membrane 3
- naked mole-rat(101713508) ATPase, Ca++ transporting, plasma membrane 3
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