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Merck

ARHGEF7

Rho guanine nucleotide exchange factor (GEF) 7

Synonyms:
BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB
Species:
Human ARHGEF7 (8874), Mouse Arhgef7 (54126), Rat Arhgef7 (114559), domestic cat ARHGEF7 (101090075), chicken ARHGEF7 (418761), dog ARHGEF7 (485552), domestic guinea pig Arhgef7 (100717780), naked mole-rat Arhgef7 (101713994), Horse ARHGEF7 (100066489), cow ARHGEF7 (524352)
UniProtKB ID:
Q14155, B1ALK6, B1ALK8, Q3LIA4, Q5W9H0, Q6P9G3, Q6PII2, Q86W63
Gene ID:
  • Human(8874) Summary: Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(54126) Rho guanine nucleotide exchange factor (GEF7)
  • Rat(114559) Rho guanine nucleotide exchange factor (GEF) 7
  • domestic cat(101090075) Rho guanine nucleotide exchange factor (GEF) 7
  • chicken(418761) Rho guanine nucleotide exchange factor (GEF) 7
  • dog(485552) Rho guanine nucleotide exchange factor (GEF) 7
  • domestic guinea pig(100717780) Rho guanine nucleotide exchange factor (GEF) 7
  • naked mole-rat(101713994) Rho guanine nucleotide exchange factor (GEF) 7
  • Horse(100066489) Rho guanine nucleotide exchange factor (GEF) 7
  • cow(524352) Rho guanine nucleotide exchange factor (GEF) 7
  • sheep(101116845) Rho guanine nucleotide exchange factor (GEF) 7

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4503492
Anti-ARHGEF7 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot