Skip to Content
Merck

ALDH18A1

aldehyde dehydrogenase 18 family, member A1

Synonyms:
ARCL3A, GSAS, P5CS, PYCS
Species:
Human ALDH18A1 (5832), Mouse Aldh18a1 (56454), Rat Aldh18a1 (361755), Zebrafish aldh18a1 (557186), domestic guinea pig Aldh18a1 (100716882), naked mole-rat Aldh18a1 (101713177), Horse ALDH18A1 (100061213), chicken ALDH18A1 (423976), domestic cat ALDH18A1 (101090803), sheep ALDH18A1 (101108974) ...More
UniProtKB ID:
P54886, B2R5Q4, B7Z350, B7Z5X8, B7ZLP1, D3DR44, O95952, Q3KQU2
Gene ID:
  • Human(5832) Summary: This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(56454) aldehyde dehydrogenase 18 family, member A1
  • Rat(361755) aldehyde dehydrogenase 18 family, member A1
  • Zebrafish(557186) aldehyde dehydrogenase 18 family, member A1
  • domestic guinea pig(100716882) aldehyde dehydrogenase 18 family, member A1
  • naked mole-rat(101713177) aldehyde dehydrogenase 18 family, member A1
  • Horse(100061213) aldehyde dehydrogenase 18 family, member A1
  • chicken(423976) aldehyde dehydrogenase 18 family, member A1
  • domestic cat(101090803) aldehyde dehydrogenase 18 family, member A1
  • sheep(101108974) aldehyde dehydrogenase 18 family, member A1
  • Domestic Rabbit(100352530) aldehyde dehydrogenase 18 family, member A1
  • cow(514759) aldehyde dehydrogenase 18 family, member A1
  • dog(477781) aldehyde dehydrogenase 18 family, member A1

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.