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Merck

ADAM17

ADAM metallopeptidase domain 17

Synonyms:
ADAM18, CD156B, CSVP, NISBD, TACE
Species:
UniProtKB ID:
Gene ID:
  • Human(6868) Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]
  • Mouse(11491) a disintegrin and metallopeptidase domain 17
  • Rat(57027) ADAM metallopeptidase domain 17
  • sheep(101116815) ADAM metallopeptidase domain 17
  • naked mole-rat(101720924) ADAM metallopeptidase domain 17
  • domestic guinea pig(100732916) ADAM metallopeptidase domain 17
  • chicken(421931) ADAM metallopeptidase domain 17
  • domestic cat(101089004) ADAM metallopeptidase domain 17
  • dog(475662) ADAM metallopeptidase domain 17
  • cow(517541) ADAM metallopeptidase domain 17
  • Horse(100072496) ADAM metallopeptidase domain 17

Custom & Knockdown Gene Products

ELISA

Product Number
Description
Species
Human TACE ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-ADAM 17 (pThr735) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-phospho-ADAM 17 (pThr735) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-ADAM 17 Antibody, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
western blot
Anti-TACE antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
flow cytometry

immunocytochemistry

immunofluorescence

western blot

Kits

Product Number
Description
Species
Tace Inhibitor Screening Assay Kit, Sufficient for 100 Fluorometric tests,
Species
mouse, rat, human

Proteins

Product Number
Description
Species
TACE human, recombinant, expressed in insect cells, ≥90% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ADAM17,
Species
human