ACVR1
activin A receptor, type I
Synonyms:
ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI
Species:
Human ACVR1 (90), Mouse Acvr1 (11477), Rat Acvr1 (79558), domestic guinea pig Acvr1 (100724428), naked mole-rat Acvr1 (101711343), chicken ACVR1 (395246), dog ACVR1 (478757), domestic cat ACVR1 (101091298), Horse ACVR1 (100050899), cow ACVR1 (338068)
UniProtKB ID:
Gene ID:
- Human(90) Summary: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
- Mouse(11477) activin A receptor, type 1
- Rat(79558) activin A receptor, type I
- domestic guinea pig(100724428) activin A receptor, type I
- naked mole-rat(101711343) activin A receptor, type I
- chicken(395246) activin A receptor, type I
- dog(478757) activin A receptor, type I
- domestic cat(101091298) activin A receptor, type I
- Horse(100050899) activin A receptor, type I
- cow(338068) activin A receptor, type I
- sheep(443161) activin A receptor, type I
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-ACVR1 antibody produced in mouse, clone 2D5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-ACVR1, affinity isolated antibody,
Species Reactivity
bovine, goat, guinea pig, horse, human, mouse
Application
immunohistochemistry
western blot
western blot
Anti-ACVR1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-ACVR1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
western blot
western blot
ANTI-ACTIVIN RECEPTOR TYPE IA (ACVR1) (CENTER R147) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
western blot