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Merck

ABCC2

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Synonyms:
ABC30, CMOAT, DJS, MRP2, cMRP
Species:
Human ABCC2 (1244), Mouse Abcc2 (12780), Rat Abcc2 (25303), sheep ABCC2 (101119776), Horse ABCC2 (100060654), naked mole-rat Abcc2 (101716089), domestic guinea pig Abcc2 (100718828), cow ABCC2 (520925), domestic cat ABCC2 (101085924), dog ABCC2 (403632) ...More
UniProtKB ID:
Q92887, B2RMT8, Q14022, Q5T2B1, Q92500, Q92798, Q99663, Q9UMS2
Gene ID:
  • Human(1244) Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
  • Mouse(12780) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • Rat(25303) ATP-binding cassette, subfamily C (CFTR/MRP), member 2
  • sheep(101119776) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • Horse(100060654) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • naked mole-rat(101716089) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • domestic guinea pig(100718828) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • cow(520925) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • domestic cat(101085924) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • dog(403632) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • chicken(423828) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • Zebrafish(393561) ATP-binding cassette, sub-family C (CFTR/MRP), member 2

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1403681
Monoclonal Anti-ABCC2 antibody produced in mouse, clone 2H6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
MAB4148
Anti-MRP2 Antibody, clone M2 I-4, culture supernatant, clone M2 I-4, Chemicon®,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry
western blot
M3692
Anti-MRP2 antibody, Mouse monoclonal, clone CPR96, purified from hybridoma cell culture,
Species Reactivity
human
Application
ELISA
microarray
western blot
MAB4150
Anti-MRP2 Antibody, CT, clone M2 III-6, culture supernatant, clone M2 III-6, Chemicon®,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry
western blot
HPA071145
Anti-ABCC2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

Kits

Product Number
Description
Species
MAK161
Multidrug Resistance Assay Kit, (Fluorometric MDR Assay),
Species
human, mouse, rat

Proteins

Product Number
Description
Species
APREST95076
PrEST Antigen ABCC2, Prestige Antibodies® Powered by Atlas Antibodies, buffered aqueous solution,
Species
human