Louie Group – Professor Product Portal

Professor Janis Louie

Professor Louie's research focuses on the discovery and mechanistic understanding of new reactions catalyzed by transition metal complexes.  She has developed a highly active Ni(0) catalyst that effectively mediates a variety of cycloaddition and isomerization reactions.  For example, her group developed a series of Ni(0) catalysts that mediate the cycloaddition between unsaturated hydrocarbons (e.g. diynes, enynes, alkynes) and heterocumulenes (such as CO₂ and isocyanates) as well as other derivatives (such as aldehydes, ketones, nitriles, azetidinones) to afford a variety of substituted heterocycles.  The Ni catalyzed coupling of an alkyne and an azetidinone affords 3-piperidones, a N-heterocyclic building block that is difficult to make by traditional methods.

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