U2625

Uric acid

≥99%, crystalline

• Synonym(s): 2,6,8-Trihydroxypurine
• Empirical Formula (Hill Notation): C₅H₄N₄O₃
• CAS Number: 69-93-2
• Molecular Weight: 168.11
• Beilstein: 156158
• EC Number: 200-720-7
• MDL number: MFCD00005712
• UNSPSC Code: 12352005
• PubChem Substance ID: 24900634
• NACRES: NA.55

Properties

• Assay: ≥99%
• form: crystalline
• mp: >300 °C (lit.)
• SMILES string: O=C1NC(=O)C2=C(N1)NC(=O)N2
• InChI: 1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
• InChI key: LEHOTFFKMJEONL-UHFFFAOYSA-N

Description

Application

Uric acid has been used:

• in inducing hyperuricemia in mice
• as a component of digestion fluid for the simulation of in vitro human digestion model
• in selectivity test of the glucose sensor in sweat-based diabetes monitoring

Biochem/physiol Actions

Uric acid is an insoluble catabolite produced by adenine and guanine metabolism. Accumulation of uric acid leads to gout, hyperuricemia, arthritis and renal failure. Elevated uric acid levels contributes to hypertension and pathogenesis of cardiovascular disease. Low uric acid levels associated with Parkinson′s disease and multiple sclerosis, may elicit protective functionality. High levels of uric acid in patients with chronic obstructive pulmonary disease (COPD) may serve as potential marker for diagnosis.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves