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SAB4502987

Sigma-Aldrich

Anti-TSG6 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

α-induced protein 6, TSG6, tumor necrosis factor

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 31 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
western blot: 1:500-1:1000

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TSG6(7130)

General description

Anti-TSG6 Antibody detects endogenous levels of total TSG6 protein.
Tumor necrosis factor (TNF)-α–stimulated gene 6 protein (TSG-6) is an inflammation-associated secreted protein. It has a molecular weight of about 35 kDa. TSG-6 possesses Link and CUB_C domains, along with a with a short amino-terminal sequence. The gene encoding this protein is localized on human chromosome 2q23.3.

Immunogen

The antiserum was produced against synthesized peptide derived from human TSG6.

Immunogen Range: 21-70

Biochem/physiol Actions

Tumor necrosis factor (TNF)-α–stimulated gene 6 protein (TSG-6) has been implicated in regulation of cell-cell and cell-matrix interactions during inflammation and tumorigenesis. TSG-6 possesses anti-inflammatory properties. It is also known to reduce inflammatory reactions triggered by ischemia in the heart. Thus, it might have a potential role in treating heart disease with other cells such as skeletal myoblasts, fetal myoblasts and embryonic stem cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages
Choi H, et al.
Blood (2011)
A Novel Allelic Variant of the Human TSG-6 Gene Encoding an Amino Acid Difference in the CUB Module CHROMOSOMAL LOCALIZATION, FREQUENCY ANALYSIS, MODELING, AND EXPRESSION.
Nentwich HA, et al.
The Journal of Biological Chemistry, 277(18), 15354-15362 (2002)
The anti-inflammatory protein TSG-6 regulates chemokine function by inhibiting chemokine/glycosaminoglycan interactions.
Dyer DP, et al.
The Journal of Biological Chemistry (2016)
Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6.
Ryang H L, et al.
Cell Stem Cell, 5(1), 54-63 (2009)
Krishna Prahlad Maremanda et al.
Toxicology and applied pharmacology, 385, 114788-114788 (2019-11-05)
Cigarette smoke (CS)-induced lung inflammation and Chronic Obstructive Pulmonary disease (COPD) involves mitochondrial dysfunction. Mesenchymal stem cells (MSC) and MSC-derived exosomes (EXO) are reported to show therapeutic effects in many animal models of inflammation and injury. In the present study

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