SAB4300440

Anti-NFKBIA (Ab-42) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-IKBA antibody produced in rabbit, Anti-MAD-3 antibody produced in rabbit, Anti-NFKBI antibody produced in rabbit, Anti-nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha antibody produced in rabbit
• MDL number: MFCD01633603
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~39 kDa
• species reactivity: human, mouse
• concentration: 1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (E-E-Y-E-Q)
• NCBI accession no.: NP_065390.1
• UniProt accession no.: P25963
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... NFKBIA(4792)

Description

Immunogen

Peptide sequence around aa. 40-44 (E-E-Y-E-Q), according to the protein NFKBIA.

Features and Benefits

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Target description

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable