8.52036

Fmoc-Hyp(tBu)-OH

≥98.0% (HPLC), for peptide synthesis, Novabiochem^®

• Synonym(s): Fmoc-Hyp(tBu)-OH, N-α-Fmoc-O-t.-butyl-L-trans-4-hydroxyproline
• Empirical Formula (Hill Notation): C₂₄H₂₇NO₅
• CAS Number: 122996-47-8
• Molecular Weight: 409.47
• MDL number: MFCD00151930
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• product name: Fmoc-Hyp(tBu)-OH, Novabiochem^®
• Quality Level: 200
• product line: Novabiochem^®
• Assay: ≥95.0% (acidimetric); ≥98% (TLC); ≥98.0% (HPLC)
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• mp: 63 °C
• application(s): peptide synthesis
• functional group: hydroxyl
• storage temp.: 15-25°C
• InChI: 1S/C24H27NO5/c1-24(2,3)30-15-12-21(22(26)27)25(13-15)23(28)29-14-20-18-10-6-4-8-16(18)17-9-5-7-11-19(17)20/h4-11,15,20-21H,12-14H2,1-3H3,(H,26,27)/t15-,21+/m1/s1
• InChI key: WPBXBYOKQUEIDW-VFNWGFHPSA-N

Description

General description

Standard building block for introduction of hydroxyproline amino-acid residues by Fmoc SPPS

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Application

• Rational design of plant hairpin-like peptide EcAMP1: Structural–functional correlations to reveal antibacterial and antifungal activity: Discusses the use of Fmoc-Hyp(tBu)-OH in designing peptides that exhibit significant antibacterial and antifungal properties (Barashkova et al., 2022).

Linkage

Replaces: 04-12-1078

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 95.0 %
Water (K. F.): ≤ 1.50 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable