729108

Poly(ethylene glycol) methyl ether thiol

average M_N 800, chemical modification reagent thiol reactive, methoxy, thiol

• Synonym(s): Polyethylene glycol, Methoxy PEG thiol, Methoxypolyethylene glycol thiol, PEG thiol, mPEG thiol
• Linear Formula: CH₃O(CH₂CH₂O)_nCH₂CH₂SH
• UNSPSC Code: 12162002
• NACRES: NA.23

Properties

• product name: Poly(ethylene glycol) methyl ether thiol, average M_n 800
• form: solid
• mol wt: average M_n 800
• reaction suitability: reagent type: chemical modification reagent; reactivity: thiol reactive
• impurities: ≤10% disulfide
• transition temp: T_m 32-37 °C
• Mw/Mn: ≤1.1
• Ω-end: thiol
• α-end: methoxy
• polymer architecture: shape: linear; functionality: monofunctional
• storage temp.: 2-8°C

Description

Application

Poly(ethylene glycol) methyl ether thiol can be used to functionalize Fe₃O₄@Au core-shell nanoparticles. The thiolated PEG increases the water solubility and significantly lowers the nanotoxicity.

It can be used as a precursor to synthesize PEG conjugated poly(β-amino ester) polyplexes for gene therapy.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3