- Development of a second generation palladium-catalyzed cycloalkenylation and its application to bioactive natural product synthesis.
Development of a second generation palladium-catalyzed cycloalkenylation and its application to bioactive natural product synthesis.
Natural product communications (2013-08-29)
Masahiro Toyota
PMID23980435
RESUMEN
A novel palladium-catalyzed intramolecular oxidative alkylation of unactivated olefins is described. This protocol was devised to solve one of the drawbacks of the original palladium-catalyzed cycloalkenylation that we developed. We call this new procedure the 'second generation palladium-catalyzed cycloalkenylation'. This protocol has been applied to the total syntheses of cis-195A, trans-195A, boonein, scholareins A, C, D, and alpha-skytanthine.
MATERIALES
Referencia del producto
Marca
Descripción del producto
Palladium, tube, 50mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%
Sigma-Aldrich
Palladium, evaporation slug, diam. × L 0.6 cm × 0.6 cm, 99.95% trace metals basis
Palladium, rod, 50mm, diameter 4.0mm, 99.95%
Palladium, rod, 100mm, diameter 2.0mm, 99.95%
Palladium, rod, 10mm, diameter 6.0mm, 99.95%
Palladium, foil, 25x25mm, thickness 0.50mm, as rolled, 99.99+%
Palladium, tube, 200mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.95%
Palladium, rod, 50mm, diameter 2.0mm, 99.95%
Palladium, wire reel, 1m, diameter 0.05mm, as drawn, 99.9%
Palladium, rod, 25mm, diameter 6.0mm, 99.95%
Palladium, wire reel, 0.05m, diameter 1.0mm, hard, 99.95%
Palladium, foil, light tested, 25x25mm, thickness 0.025mm, as rolled, 99.95%
Palladium, foil, light tested, 50x50mm, thickness 0.025mm, as rolled, 99.99+%
Palladium, microfoil, disks, 25mm, thinness 0.25μm, specific density 303.4μg/cm2, permanent mylar 3.5μm support, 99.99%
Palladium, rod, 50mm, diameter 6.0mm, 99.95%
Palladium, tube, 100mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.95%
Palladium, tube, 50mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.95%
Palladium, wire reel, 0.2m, diameter 0.25mm, as drawn, 99.99+%