Saltar al contenido
Merck

Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model.

Neurobiology of aging (2014-02-04)
Sung Hoon Baik, Moon-Yong Cha, Young-Min Hyun, Hansang Cho, Bashar Hamza, Dong Kyu Kim, Sun-Ho Han, Heesun Choi, Kyung Ho Kim, Minho Moon, Jeewoo Lee, Minsoo Kim, Daniel Irimia, Inhee Mook-Jung
RESUMEN

Immune responses in the brain are thought to play a role in disorders of the central nervous system, but an understanding of the process underlying how immune cells get into the brain and their fate there remains unclear. In this study, we used a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease. These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease.

MATERIALES
Referencia del producto
Marca
Descripción del producto

Sigma-Aldrich
PKH26 Red Fluorescent Cell Linker Kit for Phagocytic Cell Labeling, Distributed for Phanos Technologies