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Merck
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Key Documents

T1126

Sigma-Aldrich

Thyroglobulin from porcine thyroid gland

powder

Sinónimos:

TG human

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About This Item

Número de CAS:
9010-34-8
EC Number:
232-721-3
MDL number:
MFCD00132429
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

Porcine thyroid

form

powder

mol wt

~670 kDa

composition

Iodine, ≥0.3%

nitrogen analysis

14.0-17.5% total

technique(s)

protein purification: suitable

ash

≤4%

pI 

4.58

UniProt accession no.

F1RRV3

storage temp.

−20°C

Gene Information

pig ... TG(100156471)

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Biochem/physiol Actions

Thyroglobulin has been shown to regulate the transcription of iodide porters including sodium iodide symporter and pendrin.
Thyroglobulin is a major protein involved with iodine metabolism. It consists of an iodine-containing protein that is stored in the thyroid gland and is converted into circulating thyroxines when the thyroid is stimulated by TSH (Thyroid Stimulating Hormone) from the pituitary. Thyroglobulin is often used as a carrier protein for the production of antibodies. Its advantage as a carrier protein comes from its large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Other Notes

Electrophoretically heterogeneous.

Preparation Note

When reconstituted in water (20 mg/ml), a turbid solution with some insolubles is observed.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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