SAB4503836

Anti-phospho-STAT2 (pTyr⁶⁹⁰) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-IMD44, Anti-ISGF-3, Anti-P113, Anti-PTORCH3, Anti-STAT113
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 97 kDa
• species reactivity: human, mouse, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P52630
• UniProt accession no.: P52630
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr690)
• Gene Information: human ... STAT2(6773)

Descripción

General description

STAT2 (signal transducer and activator of transcription 2) is mapped to human chromosome 12.

Signal transducer and activator of transcription 2 (STAT2) belongs to the STAT family. The gene is located on human chromosome 12q13.3. STAT2 consists of 24 exons and has a molecular weight of 113 kDa. It consists of N-terminal domain (N), coiled-coil domain (CC), DNA-binding domain (DBD), linker domain (L), Src homology 2 domain (SH2), tyrosine phosphorylation site (Y) and transcriptional activation domain (TAD).

Immunogen

The antiserum was produced against synthesized peptide derived from human STAT2 around the phosphorylation site of Tyr690.

Immunogen Range: 656-705

Application

Anti-phospho-STAT2 (pTyr690) antibody produced in rabbit has been used in western blotting, immunofluorescence staining and flow cytometric staining.

Anti-phospho-STAT2 (pTyr⁶⁹⁰) antibody produced in rabbit has been used:

• for western blotting
• for immunofluorescence staining
• for flow cytometric staining

Biochem/physiol Actions

STAT2 (signal transducer and activator of transcription 2) participates in immunity. It plays a major role in interferon signaling pathways.

Signal transducer and activator of transcription 2 (STAT2) is activated by interferon-1 (IFN-I) and IFN-III. It aids protein-protein interactions and is essential for binding IRF9. STAT2 is required for the nuclear export of STAT2-IFN regulatory factor 9 (IRF9) and IFN-stimulated gene factor 3 (ISGF3). It plays a vital role in interactions with STAT1.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable