SAB4500662

Anti-Aggrecan (Cleaved-Asp³⁶⁹), N-Terminal antibody produced in rabbit

affinity isolated antibody

• Sinónimos: CSPCP, CSPG1, aggrecan core protein, cartilage-specific proteoglycan core protein, chondroitin sulfate proteoglycan core protein 1
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 44 kDa
• species reactivity: human, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P16112
• UniProt accession no.: P16112
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: proteolytically cleaved (Asp369)
• Gene Information: human ... ACAN(176)

Descripción

General description

Anti-Aggrecan (Cleaved-Asp³⁶⁹) Antibody detects endogenous levels of fragment of activated Aggrecan (Cleaved-Asp³⁶⁹) protein.

Aggrecan is a large aggregating chondroitin sulfate proteoglycan of the human cartilage. It is encoded by AGC1 (aggrecan) gene. It is located on human chromosome 15q26.1.

Immunogen

The antiserum was produced against synthesized peptide derived from human Aggrecan.

Immunogen Range: 320-369

Application

Anti-Aggrecan (Cleaved-Asp369), N-Terminal antibody has been used in western blotting and immunostaining.

Biochem/physiol Actions

Mutations in aggrecan results in autosomal dominant short stature with accelerated skeletal maturation. Mutation in the variable repeat region of the aggrecan gene (AGC1) leads to spondyloepiphyseal dysplasia.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable