P9297

Paromomycin sulfate salt

≥98% (TLC)

• Sinónimos: Aminosidine sulfate
• Fórmula empírica (notación de Hill): C₂₃H₄₅N₅O₁₄ · xH₂SO₄
• Número de CAS: 1263-89-4
• Peso molecular: 615.63 (free base basis)
• Beilstein/REAXYS Number: 5715182
• UNSPSC Code: 51281663
• PubChem Substance ID: 24278662
• NACRES: NA.85

Propiedades

• Quality Level: 200
• assay: ≥98% (TLC)
• form: powder
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; parasites
• mode of action: protein synthesis | interferes
• SMILES string: O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C
• InChI: 1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
• InChI key: OYJABWUHUYVDMJ-UDXJMMFXSA-N

Descripción

General description

Chemical structure: aminoglycoside

Application

Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. It has in vitro and in vivo activity similar to neomycin. It is effective against Gram-negative bacteria, Gram-positive bacteria, some protozoan species, and limited antihelminth.
It is used to study bacterial protein synthesis at the level of 16S ribosomal RNA and 30S ribosome assembly. Paromomycin is used to study cytosine-cytosine (CC) mismatch-containing RNA molecules and is used to inhibit Cryptosporidium infection of a human enterocyte cell line.

Biochem/physiol Actions

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Packaging

1g,5g,25g

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable