GF442-M

HumanKine^® TNF alpha, Human Recombinant Xeno-Free

• Sinónimos: Tumor Necrosis Factor-α, TNFa
• UNSPSC Code: 12352202
• eCl@ss: 32160405
• NACRES: NA.77

Propiedades

• assay: >95% (SDS-PAGE)
• Quality Level: 100
• impurities: <0.1 μg/mg protein endotoxin (<1 EU/μg)
• UniProt accession no.: P01375
• shipped in: dry ice

Descripción

General description

Tumor necrosis factor alpha (TNF-α), is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes.

Quality

Bioactivity assay: Determined by the dose-dependent cytotoxity of the TNF alpha sensitive cell line L-929 in the presence of
Actinomycin D. Typically <0.9 ng/mL ED50.

Physical form

HumanKine TNF alpha is manufactured using all non-animal reagents and is considered Xeno-Free

Legal Information

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Información de seguridad

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable