557450

Ruthenium Red

A blocker of transmembrane Ca²⁺ fluxes (IC₅₀ = 7 µM) that attenuates capsaicin-induced cation channel opening.

• Sinónimos: Ruthenium Red, Ammoniated Ruthenium Oxychloride, RR
• Fórmula lineal: [(NH₃)₅RuORu(NH₃)₄ORu(NH₃)₅]Cl₆
• Número de CAS: 12790-48-6
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated
• color: red-black
• solubility: ammonia: soluble; water: soluble
• shipped in: ambient
• storage temp.: 10-30°C

Descripción

General description

A blocker of transmembrane Ca²⁺ fluxes (IC₅₀ = 7 µM) that attenuates capsaicin-induced cation channel opening. Inhibits Ca²⁺-induced Ca²⁺ release from ryanodine-sensitive intracellular Ca²⁺ stores. Inhibits K⁺-stimulated catecholamine secretion (IC₅₀ = 6 µM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Blocker of transmembrane Ca2+ fluxes

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 7 µM in blocking transmembrane Ca2+ fluxes; 6 µM inhibiting K+-stimulated catecholamine secretion

Warning

Toxicity: Harmful (C)

Other Notes

Merck Index 13, 8379.
Phillippe, M. and Basa, A. 1996. Biochem. Biophys. Res. Commun. 221, 656.
Buratti, R., et al. 1995. Biochem. Biophys. Res. Commun. 213, 1082.
Hamilton, M.G. and Lundy, P.M. 1995. J. Pharmacol. Exp. Ther. 273, 940.
Gomis, A., et al. 1994. Biochem. Pharmacol. 47, 225.
Stjame, P., et al. 1994. Acta Otolaryngol. 114, 651.
Ma, J. 1993. J. Gen. Physiol.102, 1031.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable