444251-M

MMP-2/MMP-9 Inhibitor III

The MMP-2/MMP-9 Inhibitor III controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Sinónimos: MMP-2/MMP-9 Inhibitor III
• Fórmula empírica (notación de Hill): C₅₂H₇₁N₁₃O₁₄S₂
• Peso molecular: 1166.33
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 5 mg/mL
• storage temp.: −20°C

Descripción

General description

A cyclic peptide that acts as a potent inhibitor of MMP-2 (gelatinase A; IC₅₀ = 10 µM) and MMP-9 (gelatinase B; IC₅₀ = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models.

A hydrophobic cyclic peptide that acts as a potent inhibitor of MMP-2 and MMP-9 (IC₅₀ = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models. Also, phage that display this peptide specifically targets angiogenic blood vessels in vivo.

Biochem/physiol Actions

Target IC₅₀: 10 µM against MMP-2 and MMP-9

Warning

Toxicity: Standard Handling (A)

Sequence

H-Cys¹-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys¹⁰-OH (cyclic: 1→ 10)

Other Notes

Medina, O.P., et al. 2001. Cancer Res.61, 3978.
Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.

Legal Information

Sold under license of U.S. Patent 6,624,144.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable